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KMID : 1123920030170041065
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 4 p.1065 ~ p.1074
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Effects of Kamiyukgunja-tang on anti-CD40 and Recombinant Interleukin-4 induced Cytokine Production and Immunoglobulin E in Highly Purified Mouse B Cells
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Kim Woon-Gil
Kim Dong-Hee
Park Yang-Chun
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Abstract
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In order to evaluate the antiallergic effects of Kamiyukgunja-tang (KYGJT), studies were done. We measured the cytotoxic activity for lung fibroblast cell, cytokines transcript expression, production of INF-γ, IL-10, IL-4, GM-CSF, IL-1 β, TNF-α. IL-5 proliferation of B cell in anti-CD40mAb plus r1L-4 stimulated murine splenic B cells. The results were obtained as follows : 1. KYGJT was not showed cytotoxicity in the fibroblast lung cell. 2. KYGJT increased the gene synthesis of INF-γ, IL-10, GM-CSF(m-RNA). 3. KYGJT decreased the gene synthesis of IL-1β, IL-4, TNF-α, IL-5(m-RNA). 4. KYGJT decreased the appearance of TNF-α significantly. 5. KYGJT decreased the appearance of IgE significantly. 6. KYGJT decreased the proliferation of B cell significantly. 7. KYGJT decreased the appearance of Histamin Release Production significantly. The facts above prove that KYGJT is effective against the allergy. Thus. I think that we should study on this continuously
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KEYWORD
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Kamiyukgunja-tang(加味六君子湯), antiallergic, cytotoxicity, B cells, cytokines
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